Cagrilintide

Cagrilintide – Research Grade (≥99% Purity)

Cagrilintide is a novel, long‑acting amylin analog designed for preclinical metabolic research. It is a selective agonist at the amylin receptor (calcitonin receptor/receptor activity modifying protein complex), which plays a key role in regulating appetite, gastric emptying, and energy balance. Cagrilintide is structurally engineered with a fatty acid side chain that prolongs its half‑life, making it suitable for once‑weekly dosing schedules in research models.

Technical Specifications:

• CAS Number: 1638755-17-5
• Molecular Formula: C₂₅₆H₄₁₀N₇₀O₈₁
• Molecular Weight: Approximately 5,835 g/mol
• Purity: ≥99% by HPLC
• Mass Spectrometry: Verified
• Form: Lyophilized white powder
• Storage: -20°C, desiccated, light‑protected
• COA Provided: Yes, batch‑specific

Mechanism of Action:
Cagrilintide acts as a potent and selective amylin receptor agonist. Activation of amylin receptors in the area postrema and nucleus tractus solitarius leads to reduced caloric intake, slowed gastric emptying, and suppression of glucagon secretion. Its fatty acid acylation promotes reversible albumin binding, extending the elimination half‑life and allowing sustained receptor activation. Cagrilintide is frequently studied in combination with GLP‑1 receptor agonists (e.g., semaglutide) to investigate additive or synergistic effects on body weight regulation and glucose homeostasis.

FOR LABORATORY RESEARCH USE ONLY. Not for human or animal consumption, therapeutic, or diagnostic use. Must be handled by qualified professionals in a controlled research environment.